7月出版物快報(bào)部分亮點(diǎn)文章:
一項(xiàng)采用Seahorse 工具的篩查研究表明,基因改造秀麗隱桿線蟲(chóng)疾病模型存在 mtDNA 線粒體疾病,并且確認(rèn)了與線粒體疾病相關(guān)的 mtDNA:Haroon, S., et al. Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. (多種分子機(jī)理參與秀麗隱桿線蟲(chóng) mtDNA 疾病)Cell Rep. 2018. 22 (12): 3115-3125.一項(xiàng)實(shí)時(shí)細(xì)胞活化研究表明,糖酵解重組是樹(shù)突狀細(xì)胞活化和遷移的關(guān)鍵驅(qū)動(dòng)因素。
Guak, H., et al. Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration. (糖酵解代謝在 CCR7 寡聚化和樹(shù)突狀細(xì)胞遷移中的重要作用)Nat Commun. 2018. 9 (1): 2463.一項(xiàng)干細(xì)胞研究表明,表觀遺傳調(diào)控能夠改善神經(jīng)分化效率:
Uittenbogaard, M., et al. Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells. (表觀遺傳調(diào)節(jié)劑通過(guò)促進(jìn)線粒體形成和氧化代謝,介導(dǎo)神經(jīng)前體細(xì)胞分化增強(qiáng))Cell Death Dis. 2018. 9 (3): 360.
利用安捷倫Seahorse XF 技術(shù)通過(guò)同時(shí)實(shí)時(shí)測(cè)定活細(xì)胞的兩種主要代謝途徑——呼吸和糖酵解,專(zhuān)業(yè)的設(shè)備,專(zhuān)業(yè)的實(shí)驗(yàn)人員,為科研解決難題。